Premature ejaculation pills, with so many options, how do you know which ones work and which ones to avoid? We've got the answers.
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Premature ejaculation pills are prescription and over-the-counter medications that have been found to help treat PE. Some examples of these type pills include:
It should be noted that the Food and Drug Administration hasn't specifically approved these medications for PE. Nonetheless, it’s worth consulting with your doctor to see if they may be a good option for you.
The most popular medications for premature ejaculation are Dapoxetine (Priligy), Lexapro, Zoloft.
While these drugs may help most men, you should be conscious of the side effects that many premature ejaculations pills bring. Symptoms such as diarrhea, dizziness, dry mouth, headache, insomnia, nausea, and loss of libido can occur.
A safe and effective alternative is Promescent® Desensitizing Spray, but you can also try a more holistic approach such as doing Kegels, using the squeeze technique, or trying the edging method.
Here are some of the best delay pills to consider taking to treat premature ejaculation.
In some cases, premature ejaculation can be physiological. SSRIs work as early ejaculation pills by increasing central serotonin neurotransmission.
Paroxetine (Paxil) has been shown to be an effective treatment for premature ejaculation and is well-tolerated on a daily or as-needed basis.
According to research, Paroxetine appears to have more clinical benefits than placebo, fluoxetine, and escitalopram.
AIPE, or Arabic index of premature ejaculation, is a scoring system researchers used to determine if men were suffering from premature ejaculation.
Men with AIPE scores below 30 were diagnosed with PE, while men with scores above 30 were not diagnosed with PE.
In a study of 100 men who had an AIPE score below 30, all experienced a significant increase in their total score after taking escitalopram with few side effects.
A scientific study confirmed that citalopram (Celexa) can delay ejaculation in those suffering from PE.
The same research found that citalopram did not affect sexual desire or penile erection according to an objective assessment done by RigiScan.
When compared with fluoxetine, citalopram had a more statistically significant effect on ejaculation latency time.
Findings suggest that sertraline (Zoloft) can be potentially effective as a premature ejaculation medicine.
Men with a mean ejaculatory interval were each prescribed 25 mg daily, and then increased to 50 mg after 3 weeks, and 100 mg after a further 3 weeks. The results were as follows:
While the majority of men experienced no side effects, some participants did experience anxiety, dizziness, drowsiness, and erectile dysfunction.
When dosage was increased to 50 mg and 100 mg, some men experienced anejaculation, which is when orgasm occurs but semen isn’t released from the penis.
Fluoxetine was found to provide a significant improvement to ejaculation latency time in men suffering from PE.
The amount of men who rated their ejaculatory control as poor decreased from 98% to 41%.
High personal distress rates among the participants decreased from 47% to 11%, and high partner distress rates decreased from 72% to 27%.
Clomipramine is an SSRI used to treat OCD and has shown promise when increasing ejaculatory latency in men with primary premature ejaculation.
Ejaculation time during sexual activity increased on average from approximately 2 to 8 minutes in men with PE.
Further investigation has shown, however, that clomipramine is not effective for men with premature ejaculation plus erectile dysfunction.
Dapoxetine is an SSRI that was specifically developed for the treatment of PE. Participants in a study took the drug 1-3 hours prior to planned sexual activity.
In a study of men who took dapoxetine, more women reported that their partners' ejaculatory control was good or very good.
A majority of participants also reported their PE was slightly better than taking a placebo.
Dapoxetine is well tolerated with limited side effects and doesn't interact with ED pills such as tadalafil or sildenafil.
Tramadol hydrochloride is an opioid analgesic prescribed to treat moderate to severe pain. However, research has shown that it can help delay ejaculation.
300 participants in a study were given different dosages of tramadol. After collecting the data, it was found that all participants experienced a highly significant increase in their mean intravaginal ejaculatory latency time.
The researchers concluded that tramadol at different doses on demand is effective, safe, and tolerable for treating PE.
Sildenafil was found to have a higher efficacy in treating premature ejaculation than paroxetine and the squeeze technique.
An additional study also concluded that sildenafil combined with paroxetine significantly prolonged intravaginal ejaculation latency time and was associated with better intercourse satisfaction.
Similar to sildenafil, tadalafil was also proven to increase ejaculatory latency time in comparison to a placebo.
Even more noteworthy, two years after cessation of tadalafil, there was still a statistically significant improvement in the IELT.
Modafinil is typically used to treat conditions that cause daytime sleepiness. In patients with lifelong PE, it’s also been found to help increase IELT.
Patients who had taken modafinil reported having better control over ejaculation and improved satisfaction with sexual intercourse.
The patients also noted that they had lesser personal distress and reduced interpersonal difficulty.
Alpha blockers, including silodosin, tamsulosin, alfuzosin, and terazosin, were all found to be helpful in treating PE.
In particular, silodosin was found to be the most effective in improving the quality of life of premature ejaculation patients.
In a 2014 study, 300 patients were given 8 weeks of treatment with Yimusake Tablet. There were also 4 weeks in which the patients were not given any treatment.
Of the 288 that completed the trial, it was found that the mean IELT of the patients increased from 62.5 seconds to 168.9 seconds after 4 weeks of treatment. After 8 weeks, the mean IELT increased to 222.2 seconds.
Over-the-counter (OTC) lidocaine-based ejaculation-delaying spray has been shown to increase the time to ejaculation and overall sexual satisfaction in men struggling with subjective PE.
Applying topical lidocaine-prilocaine spray like Promescent to the underside and glans of the penis treats premature ejaculation by reducing sensation and delaying orgasm.
When taking Promescent, participants in a study saw their average IELT increase from 6.81 minutes to 11.16 minutes.
In one study, benzocaine wipes applied prior to sexual intercourse resulted in a statistically significant prolongation of time to ejaculation.
By the second month of treatment, men who were using benzocaine wipes had a mean IELT of 329.70s. 88% of the men who were treated were considered to no longer have PE.
Lidocaine cream works for treating PE by reducing nerve activity in the penis. Medication for premature ejaculation that includes lidocaine also increases intravaginal ejaculatory time.
Topical lidocaine creams are applied 20 minutes before sexual contact, and the effects can last up to 3 hours.
Research discovered that participants who applied lidocaine cream for 20 minutes prior to sex had their pre-ejaculation period increase to 6.71 minutes.
It should be noted when cream was applied for 30 minutes and 45 minutes, a majority of patients experienced erection loss due to numbness.
The stop-start method consists of penis stimulation until just before ejaculation, then stopping the stimulation until the urge to orgasm has passed.
Studies have demonstrated that the stop-start method helps increase the time spent in the vagina.
Stop-start was found to be most effective when used at the same time as sphincter control training.
These are exercises that are designed to provide patients more awareness and control of the external urethral sphincter and its role in the ejaculatory reflex.
The squeeze method involves an individual or their partner squeezing the penis until the urge to orgasm or ejaculate has gone away.
It’s been described in some research studies as partially effective in preventing premature ejaculation.
Researchers noted that despite showing a high success rate for short-term management of PE, the success rate is poor for long-term management.
For some men, difficulty delaying ejaculation is due to having a weak pelvic floor. Strengthening pelvic floor muscles helps men to gain control of their ejaculatory reflex and extend IELT.
Results from a study of 40 PE patients showed that 82.5% were able to regain control of ejaculatory reflex. IELT increased from 39.8 seconds to 112.6. seconds.
While drugs may be an effective PE treatment for some men, in other cases, a combination of treatment may be required.
In a systematic review of behavioral therapies for management of PE, researchers concluded that behavioral therapies combined with drug treatments gave better treatment outcomes than drugs alone.
A group of researchers investigated whether thickened condoms could help with delaying ejaculation.
Through their research, they discovered that thickened condoms physically preserved and extended the time of penile erection, and helped patients resist premature ejaculation.
Total erection time was higher in the thickened condom group compared to the ordinary condom group.
While more research is needed, one study found that Botulinum-A toxin (Botox) could potentially be a safe and effective means to prolong ejaculatory latency.
It was theorized that rhythmic contractions of muscles involved in the ejection phase of ejaculation may be inhibited by the injection of botulinum-A toxin.
There are a variety of medications that can potentially help treat premature ejaculation.
These include SSRIs, Pain relievers, ED pills, Modanafil, Alpha Blockers, and Chinese herbal medicine.
Most of these medications have been found to cause only mild side effects if any at all.
Nonetheless, patients may find that drugs alone won’t help. In this case, behavioral techniques, a combination of behavioral techniques and drugs, or other alternative treatments might be more helpful
Patients should consult with a doctor to determine their best option before starting a treatment plan for premature ejaculation.
Dr. Gary Bellman is a board certified urologist specializing in Men's Health. He is the owner and founder of the Southern California Urology Institute and has 30 years of experience taking care of men's health issues.
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Zhang D, Cheng Y, Wu K, Ma Q, Jiang J, Yan Z. Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis. BMC Urol. 2019;19(1):2. Published 2019 Jan 3. doi:10.1186/s12894-018-0431-7. Accessed on Mar, 27, 2024.
Arafa M, Shamloul R. A randomized study examining the effect of 3 SSRI on premature ejaculation using a validated questionnaire. Ther Clin Risk Manag. 2007;3(4):527-531. Accessed on Mar, 27, 2024.
Madeo B, Bettica P, Milleri S, Balestrieri A, Granata AR, Carani C, Rochira V. The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study. J Sex Med. 2008 Oct;5(10):2431-41. doi: 10.1111/j.1743-6109.2008.00843.x. Epub 2008 Apr 11. PMID: 18410297. Accessed on Mar, 27, 2024.
McMahon CG. Treatment of premature ejaculation with sertraline hydrochloride. Int J Impot Res. 1998 Sep;10(3):181-4; discussion 185. doi: 10.1038/sj.ijir.3900344. PMID: 9788108. Accessed on Mar, 27, 2024.
Jenkins LC, Gonzalez J, Tal R, Guhring P, Parker M, Mulhall JP. Compliance With Fluoxetine Use in Men With Primary Premature Ejaculation. J Sex Med. 2019;16(12):1895-1899. doi:10.1016/j.jsxm.2019.09.017. Accessed on Mar, 27, 2024.
Haensel SM, Rowland DL, Kallan KT. Clomipramine and sexual function in men with premature ejaculation and controls. J Urol. 1996 Oct;156(4):1310-5. PMID: 8808861. Accessed on Mar, 27, 2024.
McMahon CG. Efficacy of dapoxetine in the treatment of premature ejaculation. Clin Med Insights Reprod Health. 2011;5:25-39. Published 2011 Aug 2. doi:10.4137/CMRH.S7337. Accessed on Mar, 27, 2024.
Eassa BI, El-Shazly MA. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Asian J Androl. 2013;15(1):138-142. doi:10.1038/aja.2012.96. Accessed on Mar, 27, 2024.
Wang WF, Wang Y, Minhas S, Ralph DJ. Can sildenafil treat primary premature ejaculation? A prospective clinical study. Int J Urol. 2007 Apr;14(4):331-5. doi: 10.1111/j.1442-2042.2007.01606.x. PMID: 17470165. Accessed on Mar, 27, 2024.
Hatzimouratidis K. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Clin Interv Aging. 2006;1(4):403-414. doi:10.2147/ciia.2006.1.4.403. Accessed on Mar, 27, 2024.
Mohamed Gharib T, Abdel-Al I, Elatreisy A, et al. Short- and long-term follow-up results of daily 5-mg tadalafil as a treatment for erectile dysfunction and premature ejaculation. Arab J Urol. 2022;20(1):49-53. Published 2022 Jan 23. doi:10.1080/2090598X.2021.2024695. Accessed on Mar, 27, 2024.
Tuken M, Kiremit MC, Serefoglu EC. On-demand Modafinil Improves Ejaculation Time and Patient-reported Outcomes in Men With Lifelong Premature Ejaculation. Urology. 2016 Aug;94:139-42. doi: 10.1016/j.urology.2016.04.036. Epub 2016 May 2. PMID: 27151339. Accessed on Mar, 27, 2024.
Akin Y, Gulmez H, Ates M, Bozkurt A, Nuhoglu B. Comparison of alpha blockers in treatment of premature ejaculation: a pilot clinical trial. Iran Red Crescent Med J. 2013;15(10):e13805. doi:10.5812/ircmj.13805. Accessed on Mar, 27, 2024.
Zhao LM, Jiang H, Hong K, Li FB, Xu JX, Zhang XS, Mao XM, Zhou SH, Chen B, Chen Ming, Pu XY, Zhu CB, Yang GS, Ma LH, Ma SL, Tu XA, Deng CH, Sun XZ, Yao YS, Zhang B, Lu Y, Jia JM, Ma WG. [Yimusake Tablet: safe and efficacious for premature ejaculation]. Zhonghua Nan Ke Xue. 2014 Nov;20(11):1029-34. Chinese. PMID: 25577841. Accessed on Mar, 27, 2024.
Mark KP, Kerner I. Event-level impact of Promescent on quality of sexual experience in men with subjective premature ejaculation. Int J Impot Res. 2016;28(6):216-220. doi:10.1038/ijir.2016.31. Accessed on Mar, 27, 2024.
"Randomized, Pacebo-Controlled study To Evaluate The Efficacy, Safety, And Tolerability of Benzocaine Wipes in Subjects With Premature Ejaculation - Journal of Men's Health. Oss.jomh.org, 2019, https://oss.jomh.org/files/article/20201210-71/pdf/156-Article%20Text-1399-2-10-20200506.pdf. Accessed on Mar, 27, 2024.
Atikeler MK, Gecit I, Senol FA. Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andrologia. 2002 Dec;34(6):356-9. doi: 10.1046/j.1439-0272.2002.00511.x. PMID: 12472618. Accessed on Mar, 27, 2024.
Doğan K, Keçe C. Comparison of the results of stop-start technique with stop-start technique and sphincter control training applied in premature ejaculation treatment. PLoS One. 2023;18(8):e0283091. Published 2023 Aug 10. doi:10.1371/journal.pone.0283091. Accessed on Mar, 27, 2024.
Rodríguez JE, Marzo JC, Piqueras JA. Efficacy of Sphincter Control Training (SCT) in the treatment of premature ejaculation, a new cognitive behavioral approach: A parallel-group randomized, controlled trial. PLoS One. 2019;14(2):e0212274. Published 2019 Feb 26. doi:10.1371/journal.pone.0212274. Accessed on Mar, 27, 2024.
Gillman N, Gillman M. Premature Ejaculation: Aetiology and Treatment Strategies. Med Sci (Basel). 2019;7(11):102. Published 2019 Oct 25. doi:10.3390/medsci7110102. Accessed on Mar, 27, 2024.
Pastore AL, Palleschi G, Fuschi A, et al. Pelvic floor muscle rehabilitation for patients with lifelong premature ejaculation: a novel therapeutic approach. Ther Adv Urol. 2014;6(3):83-88. doi:10.1177/1756287214523329. Accessed on Mar, 27, 2024.
Cooper K, Martyn-St James M, Kaltenthaler E, et al. Behavioral Therapies for Management of Premature Ejaculation: A Systematic Review. Sex Med. 2015;3(3):174-188. doi:10.1002/sm2.65. Accessed on Mar, 27, 2024.
Wang Z, Yu J. Efficacy evaluation of thickened condom in the treatment of premature ejaculation. Transl Androl Urol. 2022 Feb;11(2):253-259. doi: 10.21037/tau-22-8. PMID: 35280666; PMCID: PMC8899143. Accessed on Mar, 27, 2024.
McMahon CG. Emerging and investigational drugs for premature ejaculation. Transl Androl Urol. 2016;5(4):487-501. doi:10.21037/tau.2016.04.02. Accessed on Mar, 27, 2024.
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